Deletion and deletion/insertion mutations in the juxtamembrane domain of the FLT3 gene in adult acute myeloid leukemia

In contrast to FLT3 ITD mutations, in-frame deletions in the FLT3 gene have rarely been described in adult acute leukemia. We report two cases of AML with uncommon in-frame mutations in the juxtamembrane domain of the FLT3 gene: a 3-bp (c.1770_1774delCTACGinsGT; p.F590_V592delinsLF) deletion/inserti...

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Detalhes bibliográficos

Principais autores:	Kristin K. Deeb, Matthew T. Smonskey, HanChun DeFedericis, George Deeb, Sheila N.J. Sait, Meir Wetzler, Eunice S. Wang, Petr Starostik
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2014-01-01
coleção:	Leukemia Research Reports
Assuntos:	FLT3 Juxtamembrane domain Deletion/insertion Mutation Acute myeloid leukemia (AML)
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213048913000241
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