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mTOR regulates GPVI-mediated platelet activation

Abstract Background Due to mTOR (mammalian/mechanistic target of rapamycin) gene-loss mice die during embryonic development, the role of mTOR in platelets has not been evaluated using gene knockout technology. Methods A mouse model with megakaryocyte/platelet-specific deletion of mTOR was establishe...

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Principais autores: Longsheng Wang, Gang Liu, Nannan Wu, Baiyun Dai, Shuang Han, Qiaoyun Liu, Fang Huang, Zhihua Chen, Weihong Xu, Dajing Xia, Cunji Gao
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2021-05-01
סדרה:Journal of Translational Medicine
נושאים:
Platelets
mTOR
GPVI
Dense granule secretion (ATP release)
Pkcδ
גישה מקוונת:https://doi.org/10.1186/s12967-021-02756-y
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