Structural insight into the distinct regulatory mechanism of the HEPN–MNT toxin-antitoxin system in Legionella pneumophila

Abstract HEPN–MNT, a type VII TA module, comprises the HEPN toxin and the MNT antitoxin, which acts as a nucleotidyltransferase that transfers the NMP moiety to the corresponding HEPN toxin, thereby interfering with its toxicity. Here, we report crystal structures of the Legionella pneumophila HEPN–...

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Hauptverfasser:	Chenglong Jin, Cha-Hee Jeon, Heung Wan Kim, Jin Mo Kang, Yuri Choi, Sung-Min Kang, Hyung Ho Lee, Do-Hee Kim, Byung Woo Han, Bong-Jin Lee
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-11-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-024-54551-0
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