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Dihydroartemisinin (DHA) inhibits myofibroblast differentiation through inducing ferroptosis mediated by ferritinophagy

Idiopathic pulmonary fibrosis (IPF) is caused by persistent micro-injuries and aberrant repair processes. Myofibroblast differentiation in lung is a key event for abnormal repair. Dihydroartemisinin(DHA), a well-known anti-malarial drug, have been shown to alleviate pulmonary fibrosis, but its mecha...

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Principais autores: Ningning Yu, Nan Wang, Weiqun Zhang, Junyu Xue, Quan zhou, Fengai Hu, Xuelian Bai, Naiguo Liu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-03-01
coleção:Heliyon
Assuntos:
Differentiation of myofibroblasts
Ferritinophagy
FTH1
NCOA4
Dihydroartemisinin(DHA)
Pulmonary fibrosis
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2405844024033073
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