Dimethoxybenzohomoadamantane-based soluble epoxide hydrolase inhibitors: in vivo efficacy in a murine model of chemotherapy-induced neuropathic pain

The soluble epoxide hydrolase (sEH) has recently emerged as a promising target for the treatment of several pain-related conditions. Herein, we report the design and synthesis of a peripherally restricted sEH inhibitor with high potency and good Drug Metabolism and Pharmacokinetics (DMPK) properties...

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Principais autores:	Sandra Codony, Beatrice Jora, Miriam Santos-Caballero, Qiongju Qiu, Carla Calvó-Tusell, Celia Escriche, Andreea L. Turcu, Filippo Prischi, Clara Bartra, Cristina Val, Christophe Morisseau, Belén Pérez, Andrea Bertran-Mostazo, Sílvia Osuna, Rubén Corpas, Christian Griñán-Ferré, Carles Galdeano, M. Isabel Loza, Mercè Pallàs, Coral Sanfeliu, Bruce D. Hammock, José Brea, Ferran Feixas, Maria R. Conte, Enrique J. Cobos, Santiago Vázquez
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2025-12-01
Colecção:	Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:	Benzohomoadamantane epoxyeicosatrienoic acids soluble epoxide hydrolase urea chemotherapy-induced neuropathic pain
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/14756366.2025.2574990
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