A Stochastic Intracellular Model of Anthrax Infection With Spore Germination Heterogeneity

We present a stochastic mathematical model of the intracellular infection dynamics of Bacillus anthracis in macrophages. Following inhalation of B. anthracis spores, these are ingested by alveolar phagocytes. Ingested spores then begin to germinate and divide intracellularly. This can lead to the e...

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Autors principals:	Bevelynn Williams, Martín López-García, Joseph J. Gillard, Thomas R. Laws, Grant Lythe, Jonathan Carruthers, Thomas Finnie, Carmen Molina-París
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-08-01
Col·lecció:	Frontiers in Immunology
Matèries:	Bacillus anthracis Markov process intracellular model spore germination rupture size distribution approximate Bayesian computation
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.688257/full
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