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Ferroptosis as a therapeutic target in cancer: mechanisms, immune interactions, and emerging strategies

Abstract Ferroptosis is a novel form of programmed cell death defined by iron-dependent, reactive oxygen species (ROS)-mediated peroxidation of membrane phospholipids containing polyunsaturated fatty acyl chains. Since 2020, research interest in ferroptosis has surged exponentially, outpacing that o...

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Principais autores: Bufu Tang, Yaling Lin, Songhua Cai, Jingqin Ma, Wei Zhang, Tong Jiang, Ruiqing Gao, Yongjie Zhou, Xuran Jin, Yuyu Guan, Wen Zhang, Lingxiao Liu, Zhiping Yan, Peng Luo, Xudong Qu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-04-01
Serier:Molecular Cancer
Fag:
Ferroptosis
Lipid peroxidation
Tumor microenvironment
Multi-disciplinary treatment
Nanotherapy
Online adgang:https://doi.org/10.1186/s12943-026-02590-0
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