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GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation

<p>Abstract</p> <p>Background</p> <p>After liver injury, the repair process comprises activation and proliferation of hepatic stellate cells (HSCs), which produce extracellular matrix (ECM) proteins. Peroxisome proliferator-activated receptor beta/delta <b>(</b>PPARβ/δ) is highly expressed in these...

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Wedi'i Gadw mewn:
Prif Awduron: Kostadinova Radina, Montagner Alexandra, Gouranton Erwan, Fleury Sébastien, Guillou Hervé, Dombrowicz David, Desreumaux Pierre, Wahli Walter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2012-10-01
Cyfres:Cell & Bioscience
Pynciau:
Peroxisome proliferator-activated receptor β/δ
Inflammation
Fibrosis
Signaling pathways
Proliferation
Mynediad Ar-lein:http://www.cellandbioscience.com/content/2/1/34
Tagiau: Ychwanegu Tag
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