The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

Abstract Changes in the intestinal microbiome and microbiota-derived metabolites predict clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, we report that desaminotyrosine (DAT), a product of bacterial flavonoid metabolism, correlates with improved overall...

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Bibliografiske detaljer

Principais autores:	Sascha Göttert, Erik Thiele Orberg, Kaiji Fan, Paul Heinrich, Diana M. Matthe, Omer Khalid, Lena Klostermeier, Chiara Suriano, Nicholas Strieder, Claudia Gebhard, Eva Vonbrunn, Andreas Mamilos, Daniela Hirsch, Elisabeth Meedt, Karin Kleigrewe, Andreas Hiergeist, Alix Schwarz, Joachim Gläsner, Sakhila Ghimire, Laura Joachim, Florian Voll, Klaus Neuhaus, Klaus-Peter Janssen, Markus Perl, Franziska Pielmeier, Jürgen Ruland, Marina Kreutz, Daniela Weber, Christian Schmidl, Natalie Köhler, Markus Tschurtschenthaler, Petra Hoffmann, Matthias Edinger, Daniel Wolff, Florian Bassermann, Michael Rehli, Dirk Haller, Matthias Evert, Kai Hildner, Maike Büttner-Herold, Wolfgang Herr, André Gessner, Simon Heidegger, Ernst Holler, Hendrik Poeck
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2025-10-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-025-65180-6
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