Desensitization of cAMP Accumulation via Human β3-Adrenoceptors Expressed in Human Embryonic Kidney Cells by Full, Partial, and Biased Agonists

β3-Adrenoceptors couple not only to cAMP formation but, at least in some cell types, also to alternative signaling pathways such as phosphorylation of extracellular signal-regulated kinase (ERK). β3-Adrenoceptor agonists are used in long-term symptomatic treatment of the overactive bladder syndrome;...

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Principais autores:	Katerina Okeke, Martina B. Michel-Reher, Stavros Gravas, Martin C. Michel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-06-01
Colecção:	Frontiers in Pharmacology
Assuntos:	β3-adrenoceptor cAMP extracellular signal-related kinase desensitization partial agonism biased agonism
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphar.2019.00596/full
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