A longitudinal study of the 5xFAD mouse retina delineates Amyloid beta (Aβ)-mediated retinal pathology from age-related changes

Abstract Background Age-related macular degeneration (AMD) is the commonest cause of irreversible blindness in developed societies. AMD coincides with advanced age to which genetic and lifestyle factors contribute additional risks. High levels of the Alzheimer’s-linked Amyloid beta (Aβ) proteins are...

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Principais autores:	Savannah A. Lynn, Sudha Priya Soundara Pandi, Aida Sanchez-Bretano, Anna-Marie Muir, Lidia Parker, David S. Chatelet, Tutte Newall, Jennifer A. Scott, Eloise Keeling, Neil R. Smyth, Jay E. Self, Andrew J. Lotery, Helena Lee, J. Arjuna Ratnayaka
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-06-01
coleção:	Alzheimer’s Research & Therapy
Assuntos:	5xFAD Retina Mouse model Amyloid beta (Aβ) Age Retinopathy
Acesso em linha:	https://doi.org/10.1186/s13195-025-01784-w
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