Helper virus-mediated downregulation of transgene expression permits production of recalcitrant helper-dependent adenoviral vector

Helper-dependent adenoviral vectors (HDAd) that express certain transgene products are impossible to produce because the transgene product is toxic to the producer cells, especially when made in large amounts during vector production. Downregulating transgene expression from the HDAd during vector p...

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Bibliografische Detailangaben

Hauptverfasser:	Donna J Palmer, Nathan C Grove, Philip Ng
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2016-01-01
Schriftenreihe:	Molecular Therapy: Methods & Clinical Development
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2329050116301814
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