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Global Gac/Rsm regulatory system activates the biosynthesis of mupirocin by controlling the MupR/I quorum sensing system in Pseudomonas sp. NCIMB 10586

ABSTRACT The biosynthesis of mupirocin, a clinically significant antibiotic produced by Pseudomonas sp. NCIMB 10586, is activated by the N-acyl homoserine lactone (AHL) MupR/I quorum sensing (QS) system. However, to date, limited research has focused on the influence of global regulators such as the...

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Main Authors: Yuyuan Cai, Peng Huang, Vittorio Venturi, Runyao Xiong, Zheng Wang, Wei Wang, Xianqing Huang, Hongbo Hu, Xuehong Zhang
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2025-02-01
Series:Applied and Environmental Microbiology
Subjects:
GacS/GacA two-component system
mupirocin
quorum sensing
RsmY/Z
RsmA/E/I/F/N
Online Access:https://journals.asm.org/doi/10.1128/aem.01896-24
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