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Tumor Suppressor p53 Down-Regulates Programmed Cell Death Protein 4 (PDCD4) Expression

The programmed cell death protein 4 (PDCD4), a well-known tumor suppressor, inhibits translation initiation and cap-dependent translation by inhibiting the helicase activity of EIF4A. The EIF4A tends to target mRNAs with a structured 5′-UTR. In addition, PDCD4 can also prevent tumorigenesis by inhib...

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Principais autores: William H. Yang, Andrew P. George, Chiung-Min Wang, Richard H. Yang, Avery M. Duncan, Darshti Patel, Zachery D. Neil, Wei-Hsiung Yang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-01-01
Serier:Current Oncology
Fag:
p53
PDCD4
transcriptional activity
Online adgang:https://www.mdpi.com/1718-7729/30/2/124
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