The Methyltransferase DOT1L Controls Activation and Lineage Integrity in CD4+ T Cells during Infection and Inflammation

Summary: CD4+ T helper (Th) cell differentiation is controlled by lineage-specific expression of transcription factors and effector proteins, as well as silencing of lineage-promiscuous genes. Lysine methyltransferases (KMTs) comprise a major class of epigenetic enzymes that are emerging as importan...

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Principais autores:	Sebastian Scheer, Jessica Runting, Michael Bramhall, Brendan Russ, Aidil Zaini, Jessie Ellemor, Grace Rodrigues, Judy Ng, Colby Zaph
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2020-12-01
Serija:	Cell Reports
Teme:	DOT1L CD4 T cells Th1 Th2 IFN-γ Trichuris muris
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2211124720314947
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