Effects of Amyloid Beta (Aβ) Oligomers on Blood–Brain Barrier Using a 3D Microfluidic Vasculature-on-a-Chip Model

The disruption of the blood–brain barrier (BBB) in Alzheimer’s Disease (AD) is largely influenced by amyloid beta (Aβ). In this study, we developed a high-throughput microfluidic BBB model devoid of a physical membrane, featuring endothelial cells interacting with an extracellular matrix (ECM). This...

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Bibliographic Details

Main Authors:	Samuel Chidiebere Uzoechi, Boyce Edwin Collins, Cody Joseph Badeaux, Yan Li, Sang Su Kwak, Doo Yeon Kim, Daniel Todd Laskowitz, Jin-Moo Lee, Yeoheung Yun
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2024-05-01
Series:	Applied Sciences
Subjects:	blood–brain barrier microfluidic amyloid beta Alzheimer’s Disease (AD)
Online Access:	https://www.mdpi.com/2076-3417/14/9/3917
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