TLR4 mediates post-traumatic depression via kynurenine pathway activation in a murine traumatic brain injury model

IntroductionTraumatic brain injury (TBI) is a major risk factor for major depressive disorder (MDD), yet the underlying mechanisms remain poorly defined. This study demonstrates that toll-like receptor 4 (TLR4) activation drives depressive-like behaviors through dysregulation of the kynurenine pathw...

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Principais autores:	Chang-Hong Li, Bo Wang, Ruo-Bing Gao, Yan Peng, Ke Chen, Xiao-Hui Li, Ping Li
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-04-01
Series:	Frontiers in Pharmacology
Assuntos:	delayed depression kynurenine pathway (KP) TLR4 traumatic brain injury (TBI) treatment
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1744031/full
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