Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

Abstract Nonerythrocytic alphaII‐spectrin (SPTAN1) is crucial for neuronal functions, yet its role in oncogenic processes remains inadequately characterized. This study investigates the lactylation (kla) modification of SPTAN1 (SPTAN1‐kla) and its mechanistic contributions to hepatitis B virus (HBV)...

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Главные авторы:	Zengbin Wang, Dongjie Ye, Linqing Wu, Jiayu Liu, Banglun Pan, Zhu Zhang, Xiaoxia Zhang, Yuxin Yao, Nanhong Tang
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Wiley 2026-01-01
Серии:	Advanced Science
Предметы:	CD8+ Tex HCC lactylation NOTCH1/HES1 SPTAN1
Online-ссылка:	https://doi.org/10.1002/advs.202507068
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