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RETRACTED ARTICLE: Hypoxia impairs decitabine-induced expression of HLA-DR in acute myeloid leukaemia cell lines

Abstract Background Hypomethylating agents (HMA), such as azacytidine (AZA) and decitabine (DAC), are epigenetic therapies used to treat some patients with acute myeloid leukaemia (AML) and myelodysplastic syndrome. HMAs act in a replication-dependent manner to remove DNA methylation from the genome...

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Auteurs principaux: Sam Humphries, Sean M. Burnard, Courtney D. Eggins, Simon Keely, Danielle R. Bond, Heather J. Lee
Format: Artigo
Langue:Inglês
Publié: BMC 2025-01-01
Collection:Clinical Epigenetics
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Accès en ligne:https://doi.org/10.1186/s13148-025-01812-4
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