Optimized LL-37-Derived Peptides Exhibit Antitubercular Activity, Induce Membrane Disruption, and P-Type ATPase Transcriptional Responses in <i>Mycobacterium tuberculosis</i>

Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), remains a major cause of morbidity and mortality worldwide, particularly due to the emergence of drug-resistant strains. Membrane-active antimicrobial peptides (AMPs) represent attractive therapeutic candidates because they...

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Principais autores:	Paola A. Santos, Milena Maya-Hoyos, Luz Mary Salazar, Claudia Andrea Cruz, Alver Cruz-Cacais, Mayerly Giraldo-Avila, Juliana Gómez-Manchego, Lineth Valentina Triana, Carlos Y. Soto
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-04-01
coleção:	Biomolecules
Assuntos:	<i>Mycobacterium tuberculosis</i> antimicrobial peptides LL37 analog peptides P-type ATPases
Acesso em linha:	https://www.mdpi.com/2218-273X/16/5/665
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