Intranasal Immunization of Mice with Multiepitope Chimeric Vaccine Candidate Based on Conserved Autotransporters SigA, Pic and Sap, Confers Protection against <i>Shigella flexneri</i>

Shigellosis is a diarrheal disease and the World Health Organization prompts the development of a vaccine against <i>Shigella flexneri</i>. The autotransporters SigA, Pic and Sap are conserved among <i>Shigell</i>a spp. We previously designed an in silico vaccine with immunodominat epitopes from tho...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Yrvin León, Lionel Zapata, Raúl E. Molina, Gaj Okanovič, Leonardo A. Gómez, Carla Daza-Castro, Manuel Flores-Concha, José L. Reyes, Angel A. Oñate
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-10-01
Schriftenreihe:	Vaccines
Schlagworte:	bacillary dysentery <i>Shigella flexneri</i> mucosal immunity autotransporters GroEL multiepitope chimeric vaccine
Online-Zugang:	https://www.mdpi.com/2076-393X/8/4/563
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