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Oxidative stress mediates the inhibitory effects of Manzamine A on uterine leiomyoma cell proliferation and extracellular matrix deposition via SOAT inhibition

Uterine fibroids, the most common benign tumors of the myometrium in women, are characterized by abnormal extracellular matrix deposition and uterine smooth muscle cell neoplasia, with high recurrence rates. Here, we investigated the potential of the marine natural product manzamine A (Manz A), whic...

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Principais autores: Li-Chun Lin, Hsin-Yi Chang, Tzu-Ting Kuo, Hsin-Yuan Chen, Wen-Shan Liu, Yii-Jwu Lo, Shih-Min Hsia, Tsui-Chin Huang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-10-01
coleção:Redox Biology
Assuntos:
Manzamine A
Uterine fibroid
SOAT
Cholesterol esterification
Oxidative stress
ER stress
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231723002628
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