Vitamin B12 promotes cefiderocol resistance and small-colony variants in carbapenem-resistant Acinetobacter baumannii

ABSTRACT Carbapenem-resistant Acinetobacter baumannii (CRAB) is a global health threat with few effective treatment options remaining. Cefiderocol, a last-resort siderophore-cephalosporin antibiotic, exploits bacterial iron transport systems via TonB-dependent receptors (TBDRs) to gain cellular entr...

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Hauptverfasser:	Vyanka Mezcord, Irene Luu, Usman Akhar, German M. Traglia, Cecilia Rodríguez, Samyar Moheb, Shayra D. Sanchez, Maria T. Soto, Maria J. Cima Clave, Rodrigo Sieira, Marisel R. Tuttobene, Alejandra Corso, Marcelo E. Tolmasky, Robert A. Bonomo, Luis A. Actis, Gauri Rao, Fernando Pasteran, Maria S. Ramirez
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2026-02-01
Schriftenreihe:	mBio
Schlagworte:	Acinetobacter baumannii cefiderocol vitamin B12 TonB-dependent receptors small-colony variants antibiotic resistance
Online-Zugang:	https://journals.asm.org/doi/10.1128/mbio.03760-25
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