Simulation of the nodal flow of mutant embryos with a small number of cilia: comparison of mechanosensing and vesicle transport hypotheses

Left–right (L-R) asymmetry in the body plan is determined by nodal flow in vertebrate embryos. Shinohara et al. (Shinohara K et al. 2012 Nat. Commun. 3, 622 (doi:10.1038/ncomms1624)) used Dpcd and Rfx3 mutant mouse embryos and showed that only a few cilia were sufficient to achieve L-R asymmetry. Ho...

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Bibliografische Detailangaben

Hauptverfasser:	Toshihiro Omori, Katja Winter, Kyosuke Shinohara, Hiroshi Hamada, Takuji Ishikawa
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	The Royal Society 2018-01-01
Schriftenreihe:	Royal Society Open Science
Schlagworte:	nodal flow left–right asymmetry boundary element method fluid–structureinteraction
Online-Zugang:	https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.180601
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