Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice
ARHGEF6 belongs to the family of guanine nucleotide exchange factors (GEFs) for Rho GTPases, and it specifically activates Rho GTPases CDC42 and RAC1. Arhgef6 is the X-linked intellectual disability gene also known as XLID46, and clinical features of patients carrying Arhgef6 mutations include intel...
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| Автори: | , , , , , , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Frontiers Media S.A.
2018-10-01
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| Серія: | Frontiers in Molecular Neuroscience |
| Предмети: | |
| Онлайн доступ: | https://www.frontiersin.org/article/10.3389/fnmol.2018.00362/full |
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