Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice

Abstract Background Postoperative cognitive dysfunction (POCD) is a common complication following anesthesia and surgery. General anesthetic isoflurane has potential neurotoxicity and induces cognitive impairments, but the exact mechanism remains unclear. Astrocytes form interconnected networks in t...

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Bibliografische Detailangaben

Hauptverfasser:	Rui Dong, Yuqiang Han, Linhao Jiang, Shuai Liu, Fujun Zhang, Liangyu Peng, Zimo Wang, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2022-03-01
Schriftenreihe:	Journal of Neuroinflammation
Schlagworte:	Isoflurane Cognitive impairment Connexin 43 Gap junctions Astrocytic network Neuroinflammation
Online-Zugang:	https://doi.org/10.1186/s12974-022-02424-y
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