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Structure of the core human NADPH oxidase NOX2

NADPH oxidase NOX2 produces superoxide, a reactive oxygen species essential in innate immunity. Here, the authors reveal the structure of the NOX2 core, rationalize disease-causing mutations, and suggest avenues for selective NOX2 pharmacological modulation.

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Autori principali: Sigrid Noreng, Naruhisa Ota, Yonglian Sun, Hoangdung Ho, Matthew Johnson, Christopher P. Arthur, Kellen Schneider, Isabelle Lehoux, Christopher W. Davies, Kyle Mortara, Kit Wong, Dhaya Seshasayee, Matthieu Masureel, Jian Payandeh, Tangsheng Yi, James T. Koerber
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2022-10-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-022-33711-0
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