CHIT1 at diagnosis predicts faster disability progression and reflects early microglial activation in multiple sclerosis

Abstract Multiple sclerosis (MS) is characterized by heterogeneity in disease course and prediction of long-term outcome remains a major challenge. Here, we investigate five myeloid markers – CHIT1, CHI3L1, sTREM2, GPNMB and CCL18 – in the cerebrospinal fluid (CSF) at diagnostic lumbar puncture in a...

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Detalhes bibliográficos

Principais autores:	Jarne Beliën, Stijn Swinnen, Robbe D’hondt, Laia Verdú de Juan, Nina Dedoncker, Patrick Matthys, Jan Bauer, Celine Vens, Sinéad Moylett, Bénédicte Dubois
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-06-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-024-49312-y
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