Genome-replicating HC-AdV: A novel high-capacity adenoviral vector class featuring enhanced in situ payload expression

High-capacity adenoviral (HC-AdV) vectors offer large transgene capacities and long-term expression of therapeutics but require high doses due to limited transgene expression. In contrast, replication-competent AdV (RC-AdV) vectors enhance in situ transgene expression by genome replication and incre...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Jonas Kolibius, Fabian Weiss, Patrick C. Freitag, Andreas Plückthun
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Elsevier 2025-12-01
श्रृंखला:	Molecular Therapy: Methods & Clinical Development
विषय:	adenovirus gene therapy genome targeting cell delivery high-capacity adenovirus vector genome replication
ऑनलाइन पहुंच:	http://www.sciencedirect.com/science/article/pii/S2329050125001779
टैग:	टैग जोड़ें कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!