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cAMP Receptor Protein Positively Regulates the Expression of Genes Involved in the Biosynthesis of Klebsiella oxytoca Tilivalline Cytotoxin

Klebsiella oxytoca is a resident of the human gut. However, certain K. oxytoca toxigenic strains exist that secrete the nonribosomal peptide tilivalline (TV) cytotoxin. TV is a pyrrolobenzodiazepine that causes antibiotic-associated hemorrhagic colitis (AAHC). The biosynthesis of TV is driven by enz...

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Principais autores: Diana Rodríguez-Valverde, Nancy León-Montes, Jorge Soria-Bustos, Jessica Martínez-Cruz, Ricardo González-Ugalde, Sandra Rivera-Gutiérrez, Jorge A. González-y-Merchand, Roberto Rosales-Reyes, Lázaro García-Morales, Hidetada Hirakawa, James G. Fox, Jorge A. Girón, Miguel A. De la Cruz, Miguel A. Ares
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-09-01
Serier:Frontiers in Microbiology
Fag:
CRP
tilivalline cytotoxin
aroX
npsA
Klebsiella oxytoca
Online adgang:https://www.frontiersin.org/articles/10.3389/fmicb.2021.743594/full
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