Target receptor expression dictates the selective intra-tumoral targeting of CD8+ T cells by eciskafusp alfa in matched PBMCs and TILs from CPI-naïve patients

IntroductionImmune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have shown considerable promise as a therapeutic modality in oncology. Despite their ability to target stem-like CD8+ T cells and give rise to exhaustion-fated effector CD8+ T cells, a significant subset of patients do not...

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Principais autores:	Amrita Manchala, Eleni Maria Varypataki, Jehad Charo, Pablo Umaña, Christian Klein, Laura Codarri Deak
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
coleção:	Frontiers in Immunology
Assuntos:	cis-targeting eciskafusp alfa IL-2R agonism immunocytokine preferential targeting receptor density
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1843841/full
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