Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson’s disease

Abstract Here we report the application of a mass spectrometry-based technology, imaging mass cytometry, to perform in-depth proteomic profiling of mitochondrial complexes in single neurons, using metal-conjugated antibodies to label post-mortem human midbrain sections. Mitochondrial dysfunction, pa...

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Autores principales:	Chun Chen, David McDonald, Alasdair Blain, Ashwin Sachdeva, Laura Bone, Anna L. M. Smith, Charlotte Warren, Sarah J. Pickett, Gavin Hudson, Andrew Filby, Amy E. Vincent, Doug M. Turnbull, Amy K. Reeve
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2021-05-01
Colección:	npj Parkinson's Disease
Acceso en línea:	https://doi.org/10.1038/s41531-021-00182-x
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