Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling

Abstract Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic breast cancer, in particular to aromatase inhibito...

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Bibliografiske detaljer

Principais autores:	Tommaso De Marchi, Chun-Fui Lai, Georgia M. Simmons, Isabella Goldsbrough, Alison Harrod, Thai Lam, Lakjaya Buluwela, Sven Kjellström, Christian Brueffer, Lao H. Saal, Johan Malmström, Simak Ali, Emma Niméus
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2024-03-01
Serier:	Scientific Reports
Online adgang:	https://doi.org/10.1038/s41598-024-56412-8
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