Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands

For a variety of cancer types, platinum compounds are still among the best treatment options. However, their application is limited by side effects and drug resistance. Consequently, multi-targeted platinum(IV) prodrugs that target specific traits of the malignant tissue are interesting new candidat...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Theresa Mendrina, Isabella Poetsch, Hemma Schueffl, Dina Baier, Christine Pirker, Alexander Ries, Bernhard K. Keppler, Christian R. Kowol, Dan Gibson, Michael Grusch, Walter Berger, Petra Heffeter
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-02-01
Schriftenreihe:	Pharmaceutics
Schlagworte:	platinum(IV) phenylbutyrate cisplatin prodrug lipid metabolism Warburg effect
Online-Zugang:	https://www.mdpi.com/1999-4923/15/2/677
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