Examination of multiple UGT1A and DPYD polymorphisms has limited ability to predict the toxicity and efficacy of metastatic colorectal cancer treated with irinotecan-based chemotherapy: a retrospective analysis

Abstract Background To evaluate a new UGT1A and DPYD polymorphism panel to better predict irinotecan-induced toxicity and the clinical response in Chinese patients with metastatic colorectal cancer (mCRC). Methods The genotypes of UGT1A (UGT1A1*6, UGT1A1*27, UGT1A1*28, UGT1A7*2, UGT1A7*3, UGT1A7*4 a...

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Detalles Bibliográficos

Autores principales:	Dan Liu, Jian Li, Jing Gao, Yanyan Li, Rui Yang, Lin Shen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2017-06-01
Colección:	BMC Cancer
Materias:	Irinotecan UGT1A polymorphisms DPYD polymorphisms Metastatic colorectal cancer Toxicity Clinical response
Acceso en línea:	http://link.springer.com/article/10.1186/s12885-017-3406-2
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