Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages

Abstract Background The intravenous delivery of adult neural precursor cells (NPC) has shown promising results in enabling cerebroprotection, brain tissue remodeling, and neurological recovery in young, healthy stroke mice. However, the translation of cell-based therapies to clinical settings has en...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Dongpei Yin, Chen Wang, Yachao Qi, Ya-Chao Wang, Nina Hagemann, Ayan Mohamud Yusuf, Egor Dzyubenko, Britta Kaltwasser, Tobias Tertel, Bernd Giebel, Matthias Gunzer, Aurel Popa-Wagner, Thorsten R. Doeppner, Dirk M. Hermann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-09-01
coleção:	Journal of Neuroinflammation
Assuntos:	Anti-inflammation Cholesterol-rich diet Focal cerebral ischemia Hypercholesterolemia Light sheet microscopy Microglia/macrophage morphology
Acesso em linha:	https://doi.org/10.1186/s12974-023-02894-8
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!