Cys340Ser Mutation Abolishing S-Nitrosylation Drives GRK2 Mitochondrial Localization and Dysfunction
In cardiac pathologies, levels of G protein-coupled receptor kinase 2 (GRK2)—which is involved in receptor desensitization and internalization—are elevated. Beyond these receptor-mediated effects, GRK2 also localizes to mitochondria, where it contributes to pathology. GRK2’s activity can be inhibite...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
MDPI AG
2026-03-01
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| Seri Bilgileri: | Cells |
| Konular: | |
| Online Erişim: | https://www.mdpi.com/2073-4409/15/5/458 |
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