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Pretreatment with High Mobility Group Box-1 Monoclonal Antibody Prevents the Onset of Trigeminal Neuropathy in Mice with a Distal Infraorbital Nerve Chronic Constriction Injury

Persistent pain following orofacial surgery is not uncommon. High mobility group box 1 (HMGB1), an alarmin, is released by peripheral immune cells following nerve injury and could be related to pain associated with trigeminal nerve injury. Distal infraorbital nerve chronic constriction injury (dIoN-...

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Principais autores: Takahiro Kochi, Yoki Nakamura, Simeng Ma, Kazue Hisaoka-Nakashima, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Masahiro Irifune, Norimitsu Morioka
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-04-01
coleção:Molecules
Assuntos:
pain
microglia
trigeminal neuropathy
macrophage
high mobility group box 1
neutralizing antibody
Acesso em linha:https://www.mdpi.com/1420-3049/26/7/2035
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