CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting.

Chronic myelomonocytic leukemia (CMML) is a rare blood cancer of older adults (3 in every 1,000,000 persons) characterized by poor survival and lacking effective mutation-specific therapy. Mutations in the ubiquitin ligase Cbl occur frequently in CMML and share biological and molecular features with...

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Principais autores:	Kelly Lim, Winnie L Kan, Pramod C Nair, Monika Kutyna, Angel F Lopez, Timothy Hercus, David M Ross, Steven Lane, Chun Yew Fong, Anna Brown, Agnes Yong, David Yeung, Timothy Hughes, Devendra Hiwase, Daniel Thomas
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2024-01-01
Serija:	PLoS ONE
Online dostop:	https://doi.org/10.1371/journal.pone.0310641
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