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Pluripotency-independent induction of human trophoblast stem cells from fibroblasts

Abstract Human trophoblast stem cells (hTSCs) can be derived from embryonic stem cells (hESCs) or be induced from somatic cells by OCT4, SOX2, KLF4 and MYC (OSKM). Here we explore whether the hTSC state can be induced independently of pluripotency, and what are the mechanisms underlying its acquisit...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Moriyah Naama, Moran Rahamim, Valery Zayat, Shulamit Sebban, Ahmed Radwan, Dana Orzech, Rachel Lasry, Annael Ifrah, Mohammad Jaber, Ofra Sabag, Hazar Yassen, Areej Khatib, Silvina Epsztejn-Litman, Michal Novoselsky-Persky, Kirill Makedonski, Noy Deri, Debra Goldman-Wohl, Howard Cedar, Simcha Yagel, Rachel Eiges, Yosef Buganim
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2023-06-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-023-39104-1
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