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Keratin 17 modulates the immune topography of pancreatic cancer

Abstract Background The immune microenvironment impacts tumor growth, invasion, metastasis, and patient survival and may provide opportunities for therapeutic intervention in pancreatic ductal adenocarcinoma (PDAC). Although never studied as a potential modulator of the immune response in most cance...

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Autors principals: Lyanne Delgado-Coka, Michael Horowitz, Mariana Torrente-Goncalves, Lucia Roa-Peña, Cindy V. Leiton, Mahmudul Hasan, Sruthi Babu, Danielle Fassler, Jaymie Oentoro, Ji-Dong K Bai, Emanuel F. Petricoin, Lynn M. Matrisian, Edik Matthew Blais, Natalia Marchenko, Felicia D. Allard, Wei Jiang, Brent Larson, Andrew Hendifar, Chao Chen, Shahira Abousamra, Dimitris Samaras, Tahsin Kurc, Joel Saltz, Luisa F. Escobar-Hoyos, Kenneth R. Shroyer
Format: Artigo
Idioma:Inglês
Publicat: BMC 2024-05-01
Col·lecció:Journal of Translational Medicine
Matèries:
Keratin 17
Pancreatic ductal adenocarcinoma
Cancer immunology
Cancer biomarker
Immune microenvironment
Multiplexed immunohistochemistry
Accés en línia:https://doi.org/10.1186/s12967-024-05252-1
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