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IFNγ and TNFα optimize salivary gland mesenchymal stromal cells: an alternative to marrow- and adipose-MSCs for radiation xerostomia

Objectives: Local mesenchymal stromal cell (MSC) administration is a promising therapy for xerostomia. MSCs deploy their advantageous effects through their trophic secretome and immunomodulatory capabilities. These functions are enhanced with IFNγ pre-licensing, but the effects of TNFα pre-licensing...

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Hlavní autoři: Michele C. Larsen, Ilya Gurevic, Liliana Berube, Addie Vande Loo, Elizabeth Hanson, Ryan Adam, Valeria Manfrè, Maxwell Parker, Cristina Paz, Jacques Galipeau, Randall J. Kimple, Grace Blitzer, Sara S. McCoy
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2025-12-01
Edice:Regenerative Therapy
Témata:
Mesenchymal stromal cell
Salivary gland
Bone marrow
Adipose
Radiation
Xerostomia
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2352320425002226
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