Fusobacterium nucleatum upregulates the immune inhibitory receptor PD-L1 in colorectal cancer cells via the activation of ALPK1

Fusobacterium nucleatum is a Gram-negative oncobacterium that is associated with colorectal cancer. The molecular mechanisms utilized by F. nucleatum to promote colorectal tumor development have largely focused on adhesin-mediated binding to the tumor tissue and on the pro-inflammatory capacity of F...

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Hauptverfasser:	Coco Duizer, Moniek Salomons, Merel van Gogh, Sanne Gräve, Freke A. Schaafsma, Maaike J. Stok, Merel Sijbranda, Raghuvandhanan Kumarasamy Sivasamy, Rob J. L. Willems, Marcel R. de Zoete
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2025-12-01
Schriftenreihe:	Gut Microbes
Schlagworte:	Fusobacterium nucleatum ADP-heptose ALPK1 PD-L1 colorectal cancer immune checkpoint inhibitor therapy
Online-Zugang:	https://www.tandfonline.com/doi/10.1080/19490976.2025.2458203
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