Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum

The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.

Podrobná bibliografie

Hlavní autoři:	Chuan-Xin Yu, Bainian Feng, Wen-Hua Fan, Gu-Ping Wang, Xu-Ren Yin, Xia Chen, Li-Jun Song, Wen-Long Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2013-07-01
Edice:	Molecules
Témata:	praziquantel derivatives antischistosomal activity Schistosoma japonicum neglected tropical disease
On-line přístup:	http://www.mdpi.com/1420-3049/18/8/9163
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