Pharmacodynamic Response to Deucravacitinib, an Oral, Selective, Allosteric TYK2 Inhibitor, in a Global, Phase 2, Randomized, Double-Blind, Placebo-Controlled Psoriasis Trial

Abstract Background Psoriasis, a chronic, immune-mediated, inflammatory disease, affects 2‒3% of the population. Tyrosine kinase 2 (TYK2) mediates cytokine signaling involved in adaptive [interleukin (IL)-12, IL-23] and innate (type-I interferons) immune responses; IL-23–driven T-helper (Th)17 pathw...

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Autores principales:	Ian M. Catlett, Lu Gao, Yanhua Hu, Subhashis Banerjee, James G. Krueger
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Adis, Springer Healthcare 2024-09-01
Colección:	Dermatology and Therapy
Materias:	Cytokine Deucravacitinib Pharmacodynamics Psoriasis Tyrosine kinase 2
Acceso en línea:	https://doi.org/10.1007/s13555-024-01262-5
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