Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties.

We sought to design ubiquitin-proteasome system inhibitors active against solid cancers by targeting ubiquitin receptor RPN13 within the proteasome's 19S regulatory particle. The prototypic bis-benzylidine piperidone-based inhibitor RA190 is a michael acceptor that adducts Cysteine 88 of RPN13. In p...

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Detalhes bibliográficos

Principais autores:	Ravi K Anchoori, Marietta Tan, Ssu-Hsueh Tseng, Shiwen Peng, Ruey-Shyang Soong, Aliyah Algethami, Palmer Foran, Samarjit Das, Chenguang Wang, Tian-Li Wang, Hong Liang, Chien-Fu Hung, Richard B S Roden
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2020-01-01
coleção:	PLoS ONE
Acesso em linha:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227727&type=printable
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