Lysophosphatidic acid receptor 5 in insular cortex as a potential analgesic target in neuropathic pain

Neuropathic pain remains a significant clinical challenge and existing treatments have limited efficacy and often over rely on opioids. Pharmacological inhibition and genetic knockout of lysophosphatidic acid receptor 5 (LPA5) lead to an analgesic effect on nerve injury-induced nociceptive hypersens...

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Detalhes bibliográficos

Principais autores:	Bing Wang, Xiaozhou Feng, Kristen Woodhouse, Dilip Sharma, Xianglei Meng, Huijie Shang, Huijuan Hu, Dehui Zhang, Yanan Zhang, Jun-Xu Li, Yuan-Xiang Tao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-09-01
coleção:	Neurotherapeutics
Assuntos:	LPA5 Insular cortex Hippocampus Peripheral nerve injury Neuropathic pain
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S187874792500087X
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