Orai1–STIM1 Regulates Increased Ca²⁺ Mobilization, Leading to Contractile Duchenne Muscular Dystrophy Phenotypes in Patient-Derived Induced Pluripotent Stem Cells

Ca²⁺ overload is one of the factors leading to Duchenne muscular dystrophy (DMD) pathogenesis. However, the molecular targets of dystrophin deficiency-dependent Ca²⁺ overload and the correlation between Ca²⁺ overload and contractile DMD phenotypes in in vitro human m...

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Auteurs principaux:	Tomoya Uchimura, Hidetoshi Sakurai
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2021-10-01
Collection:	Biomedicines
Sujets:	iPSC skeletal muscle Ca<sup>2+</sup> overload store-operated Ca<sup>2+</sup> channel STIM1-Orai1
Accès en ligne:	https://www.mdpi.com/2227-9059/9/11/1589
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