Cleavage of the TrkB-FL receptor during epileptogenesis: insights from a kainic acid-induced model of epilepsy and human samples

Brain-derived neurotrophic factor (BDNF) is essential for neuronal survival, differentiation, and plasticity. In epilepsy, BDNF exhibits a dual role, exerting both antiepileptic and pro-epileptic effects. The cleavage of its main receptor, full-length tropomyosin-related kinase B (TrkB-FL), was sugg...

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Detalhes bibliográficos

Principais autores:	Leonor Ribeiro-Rodrigues, João Fonseca-Gomes, Sara L. Paulo, Ricardo Viais, Filipa F. Ribeiro, Catarina Miranda-Lourenço, Francisco M. Mouro, Rita F. Belo, Catarina B. Ferreira, Sara R. Tanqueiro, Mafalda Ferreira-Manso, Juzoh Umemori, Eero Castrén, Vítor H. Paiva, Ana M. Sebastião, Eleonora Aronica, Alexandre Rainha Campos, Carla Bentes, Sara Xapelli, Maria José Diógenes
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-05-01
coleção:	Pharmacological Research
Assuntos:	BDNF Status epilepticus TrkB-ICD Spontaneous seizures Cognition
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S104366182500132X
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