Causality of immune cells on primary sclerosing cholangitis: a bidirectional two-sample Mendelian randomization study

BackgroundObservational studies have indicated that immune dysregulation in primary sclerosing cholangitis (PSC) primarily involves intestinal-derived immune cells. However, the causal relationship between peripheral blood immune cells and PSC remains insufficiently understood.MethodsA bidirectional...

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Hlavní autoři:	Pu Wu, Sinan Xie, Yunshi Cai, Hu Liu, Yinghao Lv, Ying Yang, Yucheng He, Bangjie Yin, Tian Lan, Hong Wu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-07-01
Edice:	Frontiers in Immunology
Témata:	primary sclerosing cholangitis (PSC) Mendelian randomization (MR) immune cells genome-wide association study (GWAS) causal effect
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1395513/full
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